Addressless: A New Internet Server Model to Prevent Network Scanning

Eliminating unnecessary exposure is a principle of server security. The huge IPv6 address space enhances security by making scanning infeasible, however, with recent advances of IPv6 scanning technologies, network scanning is again threatening server security. In this paper, we propose a new model named addressless server, which separates the server into an entrance module and a main service module, and assigns an IPv6 prefix instead of an IPv6 address to the main service module. The entrance module generates a legitimate IPv6 address under this prefix by encrypting the client address, so that the client can access the main server on a destination address that is different in each connection. In this way, the model provides isolation to the main server, prevents network scanning, and minimizes exposure. Moreover it provides a novel framework that supports flexible load balancing, high-availability, and other desirable features. The model is simple and does not require any modification to the client or the network. We implement a prototype and experiments show that our model can prevent the main server from being scanned at a slight performance cost

Global thyroid cancer incidence trend and age-period-cohort model analysis based on Global Burden of Disease Study from 1990 to 2019

BackgroundIn view of the rapid increase in the incidence of thyroid cancer (TC) and the spread of overdiagnosis around the world, the quantitative evaluation of the effect of age, period and birth cohort on the incidence of TC, and the analysis of the role of different factors in the incidence trend can provide scientific basis and data support for the national health departments to formulate reasonable prevention and treatment policies.MethodsThe study collated the global burden disease study data of TC incidence from 1990 to 2019, and used APC model to analyze the contribution of age, period and birth cohort to the incidence trend of TC.ResultsThere was an obvious unfavorable upward trend in terms of age and cohort effect all over the world. Since 2007, the growth rate of risk slowed down and the risk in female even decreased since 2012, which mainly contributed to the developed countries. In all SDI countries, 2002 is the dividing point of risk between male and female. In 2019, The global age-standardized incidence rate (ASIR) of TC in the 5 SDI countries all showed a significant upward trend, with the largest upward trend in the middle SDI countries.ConclusionThe trend of rapid increase in the incidence of TC has begun to slow down, but the global incidence of TC has obvious gender and regional/national heterogeneity. Policy makers should tailor specific local strategies to the risk factors of each country to further reduce the burden of TC

Performance evaluation of the 8-inch MCP-PMT for Jinping Neutrino Experiment

Jinping Neutrino Experiment plans to deploy a new type of 8-inch MCP-PMT with high photon detection efficiency for MeV-scale neutrino measurements. This work studies the performance of the MCP-PMTs, including the photon detection efficiency, the charge resolution of the single photoelectron, the transition time spread, single photoelectron response, rates of dark counts and after pulses. We find a long tail in the charge distribution, and combined with the high photon detection efficiency, the overall energy resolution sees substantial improvements. Those results will be provided as the inputs to detector simulation and design. Our results show that the new PMT satisfies all the requirements of the Jinping Neutrino Experiment

Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

<p>Abstract</p> <p>Background</p> <p>CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells adhesion to extracellular matrix (ECM) proteins is the first step to the tumor metastasis. MMPs degrade the ECM to promote tumor metastasis. The aim of this study is to investigate the effects of small interfering RNA (siRNA) against CD147 (si-CD147) on hepatocellular carcinoma cells' (SMMC-7721) architecture and functions.</p> <p>Methods</p> <p>Flow cytometry and western blot assays were employed to detect the transfection efficiency of si-CD147. Confocal microscopy was used to determine the effects of si-CD147 on SMMC-7721 cells' cytoskeleton. Invasion assay, gelatin zymography and cell adhesion assay were employed to investigate the effects of si-CD147 on SMMC-7721 cells' invasion, gelatinase production and cell adhesive abilities. Western blot assay was utilized to detect the effects of si-CD147 on focal adhesion kinase (FAK), vinculiln and mitogen-activated protein kinase (MAPK) expression in SMMC-7721 cells.</p> <p>Results</p> <p>Downregulation of CD147 gene induced the alteration of SMMC-7721 cell cytoskeleton including actin, microtubule and vimentin filaments, and inhibited gelatinase production and expression, cells invasion, FAK and vinculin expression. si-CD147 also blocked SMMC-7721 cells adhesion to collagen IV and phosphorylation level of SAPK/JNKs. SAPK/JNKs inhibitor SP600125 inhibited gelatinase production and expression.</p> <p>Conclusion</p> <p>CD147 is required for normal tumor cell architecture and cell invasion. Downregulation of CD147 affects HCC cell structure and function. Moreover, the alteration of cell behavior may be related to SAPK/JNK Pathway. siRNA against CD147 may be a possible new approach for HCC gene therapy.</p

Simultaneous polarization transformation and amplification of multi-petawatt laser pulses in magnetized plasmas

With increasing laser peak power, the generation and manipulation of high-power laser pulses become a growing challenge for conventional solid-state optics due to their limited damage threshold. As a result, plasma-based optical components that can sustain extremely high fields are attracting increasing interest. Here, we propose a type of plasma waveplate based on magneto-optical birefringence under a transverse magnetic field, which can work under extremely high laser power. Importantly, this waveplate can simultaneously alter the polarization state and boost the peak laser power. It is demonstrated numerically that an initially linearly polarized laser pulse with 5 petawatt peak power can be converted into a circularly polarized pulse with a peak power higher than 10 petawatts by such a waveplate with a centimeter-scale diameter. The energy conversion efficiency of the polarization transformation is about 98%. The necessary waveplate thickness is shown to scale inversely with plasma electron density n e and the square of magnetic field B 0, and it is about 1 cm for n e = 3 × 10 20 cm −3 and B 0 = 100 T. The proposed plasma waveplate and other plasma-based optical components can play a critical role for the effective utilization of multi-petawatt laser systems